Validation of transparent and flexible neural implants for simultaneous electrophysiology, functional imaging, and optogenetic

Lina Koschinski, Bohdan Lenyk, Marie Jung, Irene Lenzi, Björn Kampa, Dirk Mayer, Andreas Offenhäusser, Simon Musall, and Viviana Rincón Montes, J. Mater. Chem. B (2023). https://doi.org/10.1039/D3TB01191G

Our IBI-3 colleagues and researchers from other Institutes at Research Center Jülich and at RWTH Aachen University, published an article in the themed collection ‘Emerging Investigators’ in the ‘Journal of Materials Chemistry B’.

We developed and compared transparent micro-electrocorticography arrays (µECoGs) to combine electrophysiology and functional imaging. PEDOT:PSS-based µECoGs had the best trade-off of material and physical properties for chronic in vivo experiments, showing long-term stability of up to four months. We show the possibility of performing functional mapping of electrical and calcium neural signals upon visual and tactile stimuli during widefield imaging, and even more, the correlation of network dynamics across brain regions to individual neurons located directly below the transparent electrical contacts during two-photon imaging.

FIGURE 1. Application of transparent micro-electrocorticography arrays (µECoGs) to combine electrophysiology and functional imaging. PEDOT:PSS-based µECoGs in up to 4 month in-vivo experiments, two-photon imaging, functional mapping of electrical and calcium neural signals at wide-field imaging and two-photon imaging.

Publication: Koschinski L., Lenyk B., Jung M. et al. Validation of transparent and flexible neural implants for simultaneous electrophysiology, functional imaging, and optogenetics. J. Mater. Chem. B, 2023, Advance Article. https://doi.org/10.1039/D3TB01191G

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